InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HMGA1

Summary

InnateDB Gene

IDBG-83311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGA1

Gene Name

high mobility group AT-hook 1

Synonyms

HMG-R; HMGA1A; HMGIY

Species

Homo sapiens

Ensembl Gene

ENSG00000137309

Encoded Proteins

IDBP-83317

high mobility group AT-hook 1

IDBP-83319

high mobility group AT-hook 1

IDBP-83323

high mobility group AT-hook 1

IDBP-295277

high mobility group AT-hook 1

IDBP-376036

high mobility group AT-hook 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:34236873-34246231

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000347617	ENSP00000288245
ENST00000311487	ENSP00000308227
ENST00000374116	ENSP00000363230
ENST00000401473	ENSP00000385693
ENST00000447654	ENSP00000399888
ENST00000478214

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	76 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046965	retinoid X receptor binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006268	DNA unwinding involved in DNA replication
GO:0006284	base-excision repair
GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0016032	viral process
GO:0031936	negative regulation of chromatin silencing
GO:0035986	senescence-associated heterochromatin focus assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0075713	establishment of integrated proviral latency
GO:0090402	oncogene-induced cell senescence
GO:2000774	positive regulation of cellular senescence