Homo sapiens Gene: HMGA1
Summary
InnateDB Gene IDBG-83311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGA1
Gene Name high mobility group AT-hook 1
Synonyms HMG-R; HMGA1A; HMGIY;
Species Homo sapiens
Ensembl Gene ENSG00000137309
Encoded Proteins
high mobility group AT-hook 1
high mobility group AT-hook 1
high mobility group AT-hook 1
high mobility group AT-hook 1
high mobility group AT-hook 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:34236873-34246231
Strand Forward strand
Band p21.31
Transcripts
ENST00000347617 ENSP00000288245
ENST00000311487 ENSP00000308227
ENST00000374116 ENSP00000363230
ENST00000401473 ENSP00000385693
ENST00000447654 ENSP00000399888
ENST00000478214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 76 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003680 AT DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046965 retinoid X receptor binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006268 DNA unwinding involved in DNA replication
GO:0006284 base-excision repair
GO:0006337 nucleosome disassembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0016032 viral process
GO:0031936 negative regulation of chromatin silencing
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0075713 establishment of integrated proviral latency
GO:0090402 oncogene-induced cell senescence
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005829 cytosol
GO:0035985 senescence-associated heterochromatin focus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Interactions of Vpr with host cellular proteins pathway
Integration of provirus pathway
Vpr-mediated nuclear import of PICs pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
2-LTR circle formation pathway
Autointegration results in viral DNA circles pathway
Early Phase of HIV Life Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
APOBEC3G mediated resistance to HIV-1 infection pathway
Cellular Senescence pathway
HIV Life Cycle pathway
HIV Infection pathway
Host Interactions of HIV factors pathway
Integration of viral DNA into host genomic DNA pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
Il 4 signaling pathway [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional activation
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002131 NM_145899 NM_145901 NM_145902 NM_145903 NM_145905 XM_005249061
HUGO
OMIM
CCDS CCDS4788 CCDS4789
HPRD 02829
IMGT
EMBL
GenPept
RNA Seq Atlas