InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPG

Summary

InnateDB Protein

IDBP-295387.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPG

Protein Name

capping protein (actin filament), gelsolin-like

Synonyms

AFCP; HEL-S-66; MCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000386315

InnateDB Gene

IDBG-59043 (CAPG)

Protein Structure

UniProt Annotation

Function

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Nucleus {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Macrophages and macrophage-like cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0006461	protein complex assembly
GO:0051016	barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0008290	F-actin capping protein complex
GO:0031965	nuclear membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome