Version 5.4
Homo sapiens Gene: CAPG
Summary
InnateDB Gene IDBG-59043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPG
Gene Name capping protein (actin filament), gelsolin-like
Synonyms AFCP; HEL-S-66; MCP
Species Homo sapiens
Ensembl Gene ENSG00000042493
Encoded Proteins
IDBP-59045
capping protein (actin filament), gelsolin-like
IDBP-295391
capping protein (actin filament), gelsolin-like
IDBP-295387
capping protein (actin filament), gelsolin-like
IDBP-295389
capping protein (actin filament), gelsolin-like
IDBP-295392
capping protein (actin filament), gelsolin-like
IDBP-381537
capping protein (actin filament), gelsolin-like
IDBP-381542
capping protein (actin filament), gelsolin-like
IDBP-381544
capping protein (actin filament), gelsolin-like
IDBP-381545
capping protein (actin filament), gelsolin-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85394748-85418432
Strand Reverse strand
Band p11.2
Transcripts
ENST00000263867 ENSP00000263867
ENST00000409921 ENSP00000387063
ENST00000409670 ENSP00000386315
ENST00000409724 ENSP00000386965
ENST00000409275 ENSP00000386596
ENST00000453973 ENSP00000397381
ENST00000447219 ENSP00000398232
ENST00000449030 ENSP00000403330
ENST00000439385 ENSP00000391923
ENST00000415012
ENST00000471064
ENST00000483659
ENST00000459793
ENST00000491267
ENST00000479651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006461 protein complex assembly
GO:0030031 cell projection assembly
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008290 F-actin capping protein complex
GO:0031965 nuclear membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056737
View Gene Order
ENSBTAG00000005432
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516155 Hs.687978
RefSeq NM_001256139 NM_001256140 NM_001747 XM_005264581 XM_005264582
HUGO
OMIM
CCDS CCDS1974 CCDS58715
HPRD 01088
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca