InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCP2

Summary

InnateDB Protein

IDBP-295431.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCP2

Protein Name

sterol carrier protein 2

Synonyms

NLTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCPX;

Species

Homo sapiens

Ensembl Protein

ENSP00000384569

InnateDB Gene

IDBG-98680 (SCP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008526	phosphatidylinositol transporter activity
GO:0015485	cholesterol binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0033814	propanoyl-CoA C-acyltransferase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0070538	oleic acid binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006699	bile acid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0006869	lipid transport
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0015914	phospholipid transport
GO:0032385	positive regulation of intracellular cholesterol transport
GO:0032959	inositol trisphosphate biosynthetic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045940	positive regulation of steroid metabolic process
GO:0072659	protein localization to plasma membrane
GO:1901373	lipid hydroperoxide transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003033 SCP2 sterol-binding domain
IPR014030 Beta-ketoacyl synthase, N-terminal
IPR016039 Thiolase-like
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal

PFAM

PF02036
PF00109
PF00108
PF02803

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22307

PhosphoSite