Homo sapiens Gene: SCP2
Summary
InnateDB Gene IDBG-98680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCP2
Gene Name sterol carrier protein 2
Synonyms NLTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCPX;
Species Homo sapiens
Ensembl Gene ENSG00000116171
Encoded Proteins
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
sterol carrier protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52927229-53051703
Strand Forward strand
Band p32.3
Transcripts
ENST00000371514 ENSP00000360569
ENST00000371513 ENSP00000360568
ENST00000371509 ENSP00000360564
ENST00000407246 ENSP00000384569
ENST00000408941 ENSP00000386214
ENST00000435345 ENSP00000396413
ENST00000430330 ENSP00000406636
ENST00000473584
ENST00000478631 ENSP00000435194
ENST00000484100 ENSP00000432645
ENST00000478274 ENSP00000437317
ENST00000488965 ENSP00000435783
ENST00000528311 ENSP00000434132
ENST00000528809
ENST00000529363 ENSP00000431279
ENST00000533119 ENSP00000436581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008526 phosphatidylinositol transporter activity
GO:0015485 cholesterol binding
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0033814 propanoyl-CoA C-acyltransferase activity
GO:0036042 long-chain fatty acyl-CoA binding
GO:0070538 oleic acid binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0006694 steroid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0006869 lipid transport
GO:0007031 peroxisome organization
GO:0008152 metabolic process
GO:0008206 bile acid metabolic process
GO:0015914 phospholipid transport
GO:0032385 positive regulation of intracellular cholesterol transport
GO:0032959 inositol trisphosphate biosynthetic process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045940 positive regulation of steroid metabolic process
GO:0072659 protein localization to plasma membrane
GO:1901373 lipid hydroperoxide transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
alpha-linolenic acid (ALA) metabolism pathway
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
Metabolism pathway
KEGG
Primary bile acid biosynthesis pathway
PPAR signaling pathway pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22307
TrEMBL
UniProt Splice Variant
Entrez Gene 6342
UniGene Hs.476365
RefSeq NM_001193617 NM_002979 NM_001193600 NM_001193599 NM_001007098 NM_001007100 NM_001007099 NM_001007250 XM_005271104
HUGO HGNC:10606
OMIM 184755
CCDS CCDS53319 CCDS572 CCDS53317 CCDS53318 CCDS41338 CCDS44150 CCDS44149 CCDS30719
HPRD 01700
IMGT
EMBL AC099677 AK294631 AK295214 AK308105 AL445183 BC005911 BC067108 CB997588 CH471059 CR995014 M55421 M75883 M75884 S52450 U11297 U11299 U11300 U11301 U11302 U11303 U11304 U11305 U11306 U11307 U11308 U11309 U11310 U11311 U11312 U11313
GenPept AAA03557 AAA03558 AAA03559 AAB24921 AAB41286 AAH05911 AAH67108 BAG57810 BAG58208 CAH72590 EAX06760 EAX06761
RNA Seq Atlas 6342