InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCP2

Summary

InnateDB Gene

IDBG-98680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCP2

Gene Name

sterol carrier protein 2

Synonyms

NLTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCPX

Species

Homo sapiens

Ensembl Gene

ENSG00000116171

Encoded Proteins

IDBP-98682

sterol carrier protein 2

IDBP-98684

sterol carrier protein 2

IDBP-98686

sterol carrier protein 2

IDBP-295431

sterol carrier protein 2

IDBP-295414

sterol carrier protein 2

IDBP-384412

sterol carrier protein 2

IDBP-384414

sterol carrier protein 2

IDBP-589324

sterol carrier protein 2

IDBP-592072

sterol carrier protein 2

IDBP-593778

sterol carrier protein 2

IDBP-592188

sterol carrier protein 2

IDBP-600620

sterol carrier protein 2

IDBP-603757

sterol carrier protein 2

IDBP-596221

sterol carrier protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:52927229-53051703

Strand

Forward strand

Band

p32.3

Transcripts

ENST00000371514	ENSP00000360569
ENST00000371513	ENSP00000360568
ENST00000371509	ENSP00000360564
ENST00000407246	ENSP00000384569
ENST00000408941	ENSP00000386214
ENST00000435345	ENSP00000396413
ENST00000430330	ENSP00000406636
ENST00000473584
ENST00000478631	ENSP00000435194
ENST00000484100	ENSP00000432645
ENST00000478274	ENSP00000437317
ENST00000488965	ENSP00000435783
ENST00000528311	ENSP00000434132
ENST00000528809
ENST00000529363	ENSP00000431279
ENST00000533119	ENSP00000436581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003824	catalytic activity
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008526	phosphatidylinositol transporter activity
GO:0015485	cholesterol binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0033814	propanoyl-CoA C-acyltransferase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0070538	oleic acid binding

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006694	steroid biosynthetic process
GO:0006699	bile acid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0006869	lipid transport
GO:0007031	peroxisome organization
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0015914	phospholipid transport
GO:0032385	positive regulation of intracellular cholesterol transport
GO:0032959	inositol trisphosphate biosynthetic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045940	positive regulation of steroid metabolic process
GO:0072659	protein localization to plasma membrane
GO:1901373	lipid hydroperoxide transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028603

View Gene Order

ENSBTAG00000003746

Not yet available

Pathways

NETPATH

REACTOME

REACT_121147

alpha-linolenic acid (ALA) metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121284

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa00120

Primary bile acid biosynthesis pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

6342

UniGene

Hs.476365

RefSeq

NM_001007098 NM_001007099 NM_001007100 NM_001007250 NM_001193599 NM_001193600 NM_001193617 NM_002979 XM_005271104

HUGO

HGNC:10606

OMIM

184755

CCDS

CCDS30719 CCDS41338 CCDS44149 CCDS44150 CCDS53317 CCDS53318 CCDS53319 CCDS572

HPRD

01700

IMGT

EMBL

GenPept

RNA Seq Atlas

6342