InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTNNA2

Summary

InnateDB Protein

IDBP-295435.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNNA2

Protein Name

catenin (cadherin-associated protein), alpha 2

Synonyms

CAP-R; CAPR; CT114; CTNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000384638

InnateDB Gene

IDBG-58519 (CTNNA2)

Protein Structure

UniProt Annotation

Function

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Recruited to the nucleus upon ZNF639 overexpression.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0045296	cadherin binding
GO:0051015	actin filament binding

Biological Process

GO:0007155	cell adhesion
GO:0007409	axonogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0021942	radial glia guided migration of Purkinje cell
GO:0042692	muscle cell differentiation
GO:0048813	dendrite morphogenesis
GO:0048854	brain morphogenesis
GO:0051149	positive regulation of muscle cell differentiation
GO:0051823	regulation of synapse structural plasticity
GO:0060134	prepulse inhibition

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0015629	actin cytoskeleton
GO:0016323	basolateral plasma membrane
GO:0030027	lamellipodium
GO:0030424	axon