Version 5.4
Homo sapiens Protein: SMC1B
Summary
InnateDB Protein IDBP-295666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMC1B
Protein Name structural maintenance of chromosomes 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385902
InnateDB Gene IDBG-11438 (SMC1B)
Protein Structure
UniProt Annotation
Function Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005694 chromosome
GO:0016020 membrane
GO:0030893 meiotic cohesin complex
Protein Structure and Domains
PDB ID
InterPro IPR003395 RecF/RecN/SMC, N-terminal
IPR010935 SMCs flexible hinge
IPR010989 t-SNARE
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02463
PF06470
PRINTS
PIRSF
SMART SM00968
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDV3
PhosphoSite PhosphoSite-Q8NDV3
TrEMBL
UniProt Splice Variant
Entrez Gene 27127
UniGene Hs.334176
RefSeq NP_001278430
HUGO HGNC:11112
OMIM 608685
CCDS CCDS74876
HPRD 10564
IMGT
EMBL AJ504806 AK125736 AL008718 AL021391 BC126208
GenPept AAI26209 BAC86266 CAD43404 CAQ08671 CAQ08672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca