Version 5.4
Homo sapiens Gene: SMC1B
Summary
InnateDB Gene IDBG-11438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMC1B
Gene Name structural maintenance of chromosomes 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000077935
Encoded Proteins
IDBP-11440
structural maintenance of chromosomes 1B
IDBP-295666
structural maintenance of chromosomes 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:45344063-45413619
Strand Reverse strand
Band q13.31
Transcripts
ENST00000357450 ENSP00000350036
ENST00000404354 ENSP00000385902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0007062 sister chromatid cohesion
GO:0007126 meiotic nuclear division
GO:0016192 vesicle-mediated transport
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0000800 lateral element
GO:0005694 chromosome
GO:0016020 membrane
GO:0030893 meiotic cohesin complex
GO:0034991 nuclear meiotic cohesin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022432
View Gene Order
ENSBTAG00000024132
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
hsa04110
Cell cycle pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt Q8NDV3
TrEMBL
UniProt Splice Variant
Entrez Gene 27127
UniGene Hs.334176
RefSeq NM_148674 NM_001291501 XM_005261566
HUGO HGNC:11112
OMIM 608685
CCDS CCDS43027 CCDS74876
HPRD 10564
IMGT
EMBL AJ504806 AK125736 AL008718 AL021391 BC126208
GenPept AAI26209 BAC86266 CAD43404 CAQ08671 CAQ08672
RNA Seq Atlas 27127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca