InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANTXR1

Summary

InnateDB Protein

IDBP-295683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANTXR1

Protein Name

anthrax toxin receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387058

InnateDB Gene

IDBG-54751 (ANTXR1)

Protein Structure

UniProt Annotation

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. {ECO:0000269PubMed:15777794, ECO:0000269PubMed:16762926}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

Disease Associations

Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269PubMed:18931684}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.GAPO syndrome (GAPO) [MIM:230740]: A disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients. {ECO:0000269PubMed:23602711}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. {ECO:0000269PubMed:15777794}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding