Homo sapiens Gene: ANTXR1
Summary
InnateDB Gene IDBG-54751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANTXR1
Gene Name anthrax toxin receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169604
Encoded Proteins
anthrax toxin receptor 1
anthrax toxin receptor 1
anthrax toxin receptor 1
anthrax toxin receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69013178-69249327
Strand Forward strand
Band p13.3
Transcripts
ENST00000303714 ENSP00000301945
ENST00000409349 ENSP00000386494
ENST00000409829 ENSP00000387058
ENST00000463335
ENST00000482235 ENSP00000430776
ENST00000481119
ENST00000497197
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0007165 signal transduction
GO:0022414 reproductive process
GO:0031532 actin cytoskeleton reorganization
GO:0034446 substrate adhesion-dependent cell spreading
Cellular Component
GO:0016021 integral component of membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 84168
UniGene Hs.165859 Hs.610325 Hs.625840
RefSeq NM_018153 NM_032208 NM_053034
HUGO HGNC:21014
OMIM 606410
CCDS CCDS1892 CCDS46313 CCDS46314
HPRD 05913
IMGT
EMBL
GenPept
RNA Seq Atlas 84168