InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SACM1L

Summary

InnateDB Protein

IDBP-29623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SACM1L

Protein Name

SAC1 suppressor of actin mutations 1-like (yeast)

Synonyms

SAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000373713

InnateDB Gene

IDBG-29621 (SACM1L)

Protein Structure

UniProt Annotation

Function

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, brain, lung, liver, kidney, pancreas and testis. {ECO:0000269PubMed:10048485}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004438	phosphatidylinositol-3-phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008150	biological_process
GO:0044281	small molecule metabolic process
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex