InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTN1

Summary

InnateDB Protein

IDBP-29665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTN1

Protein Name

netrin 1

Synonyms

NTN1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000173229

InnateDB Gene

IDBG-29663 (NTN1)

Protein Structure

UniProt Annotation

Function

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. {ECO:0000269PubMed:15343335}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). {ECO:0000269PubMed:20736409, ECO:0000269PubMed:9950216}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030879	mammary gland development
GO:0033564	anterior/posterior axon guidance
GO:0040023	establishment of nucleus localization
GO:0042472	inner ear morphogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045773	positive regulation of axon extension
GO:0060603	mammary gland duct morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type

PFAM

PF00053
PF00055
PF01759

PRINTS

PIRSF

SMART

SM00180
SM00136
SM00643

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95631