Homo sapiens Gene: NTN1
Summary
InnateDB Gene IDBG-29663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTN1
Gene Name netrin 1
Synonyms NTN1L;
Species Homo sapiens
Ensembl Gene ENSG00000065320
Encoded Proteins
netrin 1
netrin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NTN1 inhibits CCL2 and CCL19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ntn1 inhibits Ccl2 and Ccl19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall.
Entrez Gene
Summary Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:9021542-9244000
Strand Forward strand
Band p13.1
Transcripts
ENST00000173229 ENSP00000173229
ENST00000436734 ENSP00000389375
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001764 neuron migration
GO:0006915 apoptotic process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0008284 positive regulation of cell proliferation
GO:0016337 single organismal cell-cell adhesion
GO:0030334 regulation of cell migration
GO:0030517 negative regulation of axon extension
GO:0030879 mammary gland development
GO:0033564 anterior/posterior axon guidance
GO:0040023 establishment of nucleus localization
GO:0042472 inner ear morphogenesis
GO:0045087 innate immune response (InnateDB)
GO:0045773 positive regulation of axon extension
GO:0060603 mammary gland duct morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Developmental Biology pathway
Cell-Cell communication pathway
Axon guidance pathway
Netrin-1 signaling pathway
Role of second messengers in netrin-1 signaling pathway
DCC mediated attractive signaling pathway
DSCAM interactions pathway
Netrin mediated repulsion signals pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Netrin-mediated signaling events
Cross-References
SwissProt O95631
TrEMBL H7BZF4
UniProt Splice Variant
Entrez Gene 9423
UniGene Hs.660885
RefSeq NM_004822 XM_006721595
HUGO HGNC:8029
OMIM 601614
CCDS CCDS11148
HPRD
IMGT
EMBL AC005695 AC090610 GU727649 U75586
GenPept AAD09221 ADU87650
RNA Seq Atlas 9423