InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NTN1

Summary

InnateDB Gene

IDBG-29663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTN1

Gene Name

netrin 1

Synonyms

NTN1L

Species

Homo sapiens

Ensembl Gene

ENSG00000065320

Encoded Proteins

IDBP-29665

netrin 1

IDBP-368117

netrin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22231519

NTN1 inhibits CCL2 and CCL19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22231519

[Mus musculus] Ntn1 inhibits Ccl2 and Ccl19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall.

Entrez Gene

Summary

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:9021542-9244000

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000173229	ENSP00000173229
ENST00000436734	ENSP00000389375

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030879	mammary gland development
GO:0033564	anterior/posterior axon guidance
GO:0040023	establishment of nucleus localization
GO:0042472	inner ear morphogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045773	positive regulation of axon extension
GO:0060603	mammary gland duct morphogenesis