InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCR6

Summary

InnateDB Protein

IDBP-29995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR6

Protein Name

chemokine (C-X-C motif) receptor 6

Synonyms

BONZO; CD186; STRL33; TYMSTR;

Species

Homo sapiens

Ensembl Protein

ENSP00000304414

InnateDB Gene

IDBG-29993 (CXCR6)

Protein Structure

UniProt Annotation

Function

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in lymphoid tissues and activated T cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0015026	coreceptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0019079	viral genome replication
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR002235 CXC chemokine receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00645
PR01105

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00574