InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIAS2

Summary

InnateDB Protein

IDBP-3017.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS2

Protein Name

protein inhibitor of activated STAT, 2

Synonyms

ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4;

Species

Homo sapiens

Ensembl Protein

ENSP00000317163

InnateDB Gene

IDBG-3013 (PIAS2)

Protein Structure

UniProt Annotation

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys- 160'. {ECO:0000269PubMed:15920481, ECO:0000269PubMed:15976810, ECO:0000269PubMed:22406621}.

Subcellular Localization

Nucleus speckle. Nucleus, PML body. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs).

Disease Associations

Tissue Specificity

Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs. {ECO:0000269PubMed:11439351, ECO:0000269PubMed:15301740, ECO:0000269PubMed:9920921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	95 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0016925	protein sumoylation
GO:0030521	androgen receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060766	negative regulation of androgen receptor signaling pathway