Homo sapiens Gene: PIAS2
Summary
InnateDB Gene IDBG-3013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIAS2
Gene Name protein inhibitor of activated STAT, 2
Synonyms ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4;
Species Homo sapiens
Ensembl Gene ENSG00000078043
Encoded Proteins
protein inhibitor of activated STAT, 2
protein inhibitor of activated STAT, 2
protein inhibitor of activated STAT, 2
protein inhibitor of activated STAT, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Functions as an E3 ligase to promote STAT1 SUMO modification
Entrez Gene
Summary This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:46808390-46920160
Strand Reverse strand
Band q21.1
Transcripts
ENST00000324794 ENSP00000317163
ENST00000398654 ENSP00000381648
ENST00000545673 ENSP00000443238
ENST00000586170
ENST00000592221 ENSP00000466596
ENST00000586953 ENSP00000468166
ENST00000589917 ENSP00000465312
ENST00000592212 ENSP00000479025
ENST00000589819
ENST00000590127
ENST00000587810 ENSP00000468017
ENST00000585916 ENSP00000465676
ENST00000586634
ENST00000592011
ENST00000590944
ENST00000591865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 95 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0016925 protein sumoylation
GO:0030521 androgen receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045667 regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060766 negative regulation of androgen receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0016605 PML body
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
TGF_beta_Receptor pathway
REACTOME
KEGG
Ubiquitin mediated proteolysis pathway
Jak-STAT signaling pathway pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
PID NCI
IL12 signaling mediated by STAT4
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595787 Hs.618029 Hs.634224 Hs.735219 Hs.739149
RefSeq NM_004671 NM_173206 XM_005258377 XM_005258379 XM_005258381 XM_005258382 XM_005258383 XM_006722571 XM_006722572 XM_006722573
HUGO
OMIM
CCDS CCDS32824 CCDS32825
HPRD 06944
IMGT
EMBL
GenPept
RNA Seq Atlas