InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIB2

Summary

InnateDB Protein

IDBP-30301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIB2

Protein Name

tribbles homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000155926

InnateDB Gene

IDBG-30297 (TRIB2)

Protein Structure

UniProt Annotation

Function

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). {ECO:0000250UniProtKB:Q28283, ECO:0000250UniProtKB:Q96RU8}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=May associate with the cytoskeleton. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in peripheral blood leukocytes. {ECO:0000269PubMed:15299019}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405	regulation of MAP kinase activity
GO:0045081	negative regulation of interleukin-10 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt