Homo sapiens Gene: TRIB2
Summary
InnateDB Gene IDBG-30297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIB2
Gene Name tribbles homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000071575
Encoded Proteins
tribbles homolog 2 (Drosophila)
tribbles homolog 2 (Drosophila)
tribbles homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIB2 expression is induced by TLR5 stimulation to inhibit NF-kB signalling in epithelial cells.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Trib2 expression is induced by Tlr5 stimulation to inhibit NF-kB signalling in epithelial cells.
Entrez Gene
Summary This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:12716889-12742734
Strand Forward strand
Band p24.3
Transcripts
ENST00000381465 ENSP00000370874
ENST00000155926 ENSP00000155926
ENST00000405331 ENSP00000384260
ENST00000483034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein ligase regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405 regulation of MAP kinase activity
GO:0045081 negative regulation of interleukin-10 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045599 negative regulation of fat cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467751 Hs.627749 Hs.715073
RefSeq NM_021643
HUGO
OMIM
CCDS CCDS1683
HPRD 18224
IMGT
EMBL
GenPept
RNA Seq Atlas