InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIB2

Summary

InnateDB Gene

IDBG-30297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIB2

Gene Name

tribbles homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000071575

Encoded Proteins

IDBP-30299

tribbles homolog 2 (Drosophila)

IDBP-30301

tribbles homolog 2 (Drosophila)

IDBP-292809

tribbles homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22271508

TRIB2 expression is induced by TLR5 stimulation to inhibit NF-kB signalling in epithelial cells.

InnateDB Annotation from Orthologs

Summary

PMID 22271508

[Mus musculus] Trib2 expression is induced by Tlr5 stimulation to inhibit NF-kB signalling in epithelial cells.

Entrez Gene

Summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:12716889-12742734

Strand

Forward strand

Band

p24.3

Transcripts

ENST00000381465	ENSP00000370874
ENST00000155926	ENSP00000155926
ENST00000405331	ENSP00000384260
ENST00000483034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405	regulation of MAP kinase activity
GO:0045081	negative regulation of interleukin-10 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020601

View Gene Order

ENSBTAG00000016045

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.467751 Hs.627749 Hs.715073

RefSeq

NM_021643

HUGO

OMIM

CCDS

CCDS1683

HPRD

18224

IMGT

EMBL

GenPept

RNA Seq Atlas