InnateDB Protein
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IDBP-30327.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATOH1
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Protein Name
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atonal homolog 1 (Drosophila)
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Synonyms
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ATH1; bHLHa14; HATH1; MATH-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302216
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InnateDB Gene
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IDBG-30325 (ATOH1)
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Protein Structure
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Function |
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0031490
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chromatin DNA binding
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GO:0043565
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sequence-specific DNA binding
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q92858
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PhosphoSite |
PhosphoSite-Q92858
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TrEMBL |
Q6ISE7
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UniProt Splice Variant |
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Entrez Gene |
474
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UniGene |
Hs.532680
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RefSeq |
NP_005163
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HUGO |
HGNC:797
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OMIM |
601461
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CCDS |
CCDS3638
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HPRD |
03270
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IMGT |
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EMBL |
BC069145
BC069578
BC069594
BC069604
BC113623
BC113625
U61148
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GenPept |
AAB41305
AAH69145
AAH69578
AAH69594
AAH69604
AAI13624
AAI13626
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