Homo sapiens Gene: ATOH1
InnateDB Gene IDBG-30325.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATOH1
Gene Name atonal homolog 1 (Drosophila)
Synonyms ATH1; bHLHa14; HATH1; MATH-1
Species Homo sapiens
Ensembl Gene ENSG00000172238
Encoded Proteins
atonal homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:93828753-93830964
Strand Forward strand
Band q22.2
ENST00000306011 ENSP00000302216
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001764 neuron migration
GO:0006366 transcription from RNA polymerase II promoter
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0042472 inner ear morphogenesis
GO:0042491 auditory receptor cell differentiation
GO:0042667 auditory receptor cell fate specification
GO:0042668 auditory receptor cell fate determination
GO:0043066 negative regulation of apoptotic process
GO:0045609 positive regulation of auditory receptor cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048839 inner ear development
GO:2000982 positive regulation of inner ear receptor cell differentiation
Cellular Component
GO:0005634 nucleus
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q92858
UniProt Splice Variant
Entrez Gene 474
UniGene Hs.532680
RefSeq NM_005172
OMIM 601461
EMBL BC069145 BC069578 BC069594 BC069604 BC113623 BC113625 U61148
GenPept AAB41305 AAH69145 AAH69578 AAH69594 AAH69604 AAI13624 AAI13626
RNA Seq Atlas 474