Version 5.4
Homo sapiens Protein: TUB
Summary
InnateDB Protein IDBP-30466.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUB
Protein Name tubby homolog (mouse)
Synonyms rd5;
Species Homo sapiens
Ensembl Protein ENSP00000299506
InnateDB Gene IDBG-30462 (TUB)
Protein Structure
UniProt Annotation
Function Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269PubMed:19837063}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0032403 protein complex binding
Biological Process
GO:0006909 phagocytosis
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000007 Tubby, C-terminal
IPR005398 Tubby, N-terminal
IPR025659 Tubby C-terminal-like domain
PFAM PF01167
PRINTS PR01573
PR01574
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50607
PhosphoSite PhosphoSite-P50607
TrEMBL Q9H4D2
UniProt Splice Variant
Entrez Gene 7275
UniGene Hs.620904
RefSeq NP_813977
HUGO HGNC:12406
OMIM 601197
CCDS CCDS7787
HPRD 03121
IMGT
EMBL AJ277662 BC075031 BC075032 CH471064 U54644 U82467
GenPept AAB53494 AAB53699 AAH75031 AAH75032 CAC14586 EAW68634

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca