Version 5.4
Homo sapiens Gene: TUB
Summary
InnateDB Gene IDBG-30462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUB
Gene Name tubby homolog (mouse)
Synonyms rd5
Species Homo sapiens
Ensembl Gene ENSG00000166402
Encoded Proteins
IDBP-30464
tubby homolog (mouse)
IDBP-30466
tubby homolog (mouse)
IDBP-583142
tubby homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:8019244-8106112
Strand Forward strand
Band p15.4
Transcripts
ENST00000305253 ENSP00000305426
ENST00000299506 ENSP00000299506
ENST00000534099 ENSP00000434400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0032403 protein complex binding
Biological Process
GO:0006909 phagocytosis
GO:0007602 phototransduction
GO:0007605 sensory perception of sound
GO:0009584 detection of visible light
GO:0009725 response to hormone
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0050766 positive regulation of phagocytosis
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031028
View Gene Order
ENSBTAG00000004862
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P50607
TrEMBL Q9H4D2
UniProt Splice Variant
Entrez Gene 7275
UniGene Hs.568986 Hs.620904
RefSeq NM_003320 XM_005253109 NM_177972 XM_006718303
HUGO HGNC:12406
OMIM 601197
CCDS CCDS7786 CCDS7787
HPRD 03121
IMGT
EMBL AJ277662 BC075031 BC075032 CH471064 U54644 U82467
GenPept AAB53494 AAB53699 AAH75031 AAH75032 CAC14586 EAW68634
RNA Seq Atlas 7275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca