Homo sapiens Gene: TUB
Summary
InnateDB Gene IDBG-30462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUB
Gene Name tubby homolog (mouse)
Synonyms rd5;
Species Homo sapiens
Ensembl Gene ENSG00000166402
Encoded Proteins
tubby homolog (mouse)
tubby homolog (mouse)
tubby homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:8019244-8106112
Strand Forward strand
Band p15.4
Transcripts
ENST00000305253 ENSP00000305426
ENST00000299506 ENSP00000299506
ENST00000534099 ENSP00000434400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0032403 protein complex binding
Biological Process
GO:0006909 phagocytosis
GO:0007602 phototransduction
GO:0007605 sensory perception of sound
GO:0009584 detection of visible light
GO:0009725 response to hormone
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0050766 positive regulation of phagocytosis
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
G-protein signaling through tubby proteins [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL E9PQR4 Q9H4D2
UniProt Splice Variant
Entrez Gene 7275
UniGene Hs.568986 Hs.620904
RefSeq XM_006718303 NM_003320 NM_177972 XM_005253109
HUGO HGNC:12406
OMIM 601197
CCDS CCDS7786 CCDS7787
HPRD 03121
IMGT
EMBL AC116456 AJ277662
GenPept CAC14586
RNA Seq Atlas 7275