Homo sapiens Protein: DDX1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Protein | IDBP-30765.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | DDX1 | ||||||||||||||||||||||||||||
Protein Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 | ||||||||||||||||||||||||||||
Synonyms | DBP-RB; UKVH5d; | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000233084 | ||||||||||||||||||||||||||||
InnateDB Gene | IDBG-30761 (DDX1) | ||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||
Function | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF- kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269PubMed:12183465, ECO:0000269PubMed:15567440, ECO:0000269PubMed:18335541, ECO:0000269PubMed:18710941, ECO:0000269PubMed:20573827, ECO:0000269PubMed:24870230}. | ||||||||||||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR- induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM- dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269PubMed:24608264}. | ||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||
Tissue Specificity | Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord. {ECO:0000269PubMed:7689221}. | ||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||
InterPro |
IPR001650
Helicase, C-terminal IPR001870 B30.2/SPRY domain IPR003877 SPRY domain IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR011545 DEAD/DEAH box helicase domain IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR014014 RNA helicase, DEAD-box type, Q motif IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00271
PF00622 PF00270 |
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PRINTS | |||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||
SMART |
SM00490
SM00449 SM00487 |
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TIGRFAMs | |||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | Q92499 | ||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q92499 | ||||||||||||||||||||||||||||
TrEMBL | B4DME8 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 1653 | ||||||||||||||||||||||||||||
UniGene | Hs.440599 | ||||||||||||||||||||||||||||
RefSeq | NP_004930 | ||||||||||||||||||||||||||||
HUGO | HGNC:2734 | ||||||||||||||||||||||||||||
OMIM | 601257 | ||||||||||||||||||||||||||||
CCDS | CCDS1686 | ||||||||||||||||||||||||||||
HPRD | 03158 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AB593031 AB593032 AB593034 AK297432 AK313933 BC012132 BC053673 CH471053 EF418570 EF418571 X70649 | ||||||||||||||||||||||||||||
GenPept | AAH12132 AAH53673 ABN70940 ABN70941 BAG36652 BAG59860 BAJ83985 BAJ83986 BAJ83988 CAA49992 EAX00897 | ||||||||||||||||||||||||||||