Version 5.4
Homo sapiens Gene: DDX1
Summary
InnateDB Gene IDBG-30761.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX1
Gene Name DEAD (Asp-Glu-Ala-Asp) box helicase 1
Synonyms DBP-RB; UKVH5d
Species Homo sapiens
Ensembl Gene ENSG00000079785
Encoded Proteins
IDBP-30763
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
IDBP-30765
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
IDBP-364710
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
IDBP-809046
DEAD (Asp-Glu-Ala-Asp) box helicase 1
IDBP-809047
DEAD (Asp-Glu-Ala-Asp) box helicase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21703541
DDX1 is cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. DDX1 then recruits DDX21, DHX36 and TICAM1 to mount type I interferon and cytokine response to poly I:C, Influenza A virus and reovirus. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21703541
[Mus musculus] Ddx1 is a cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. Ddx1 then recruits Ddx21, Dhx36 and Ticam1 to mount type I interferon and cytokine response to poly I:C, influenza A virus, and reovirus.
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:15591178-15631111
Strand Forward strand
Band p24.3
Transcripts
ENST00000381341 ENSP00000370745
ENST00000233084 ENSP00000233084
ENST00000434671 ENSP00000413767
ENST00000459706
ENST00000470674
ENST00000478695
ENST00000621973 ENSP00000484958
ENST00000617198 ENSP00000482416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 130 [view]
Protein-Protein 128 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription cofactor activity
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008143 poly(A) binding
GO:0033677 DNA/RNA helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0006200 ATP catabolic process
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006446 regulation of translational initiation
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0032508 DNA duplex unwinding
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0071920 cleavage body
GO:0072669 tRNA-splicing ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037149
View Gene Order
ENSBTAG00000009906
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440599
RefSeq NM_004939
HUGO
OMIM
CCDS CCDS1686
HPRD 03158
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca