InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLL2

Summary

InnateDB Protein

IDBP-30869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLL2

Protein Name

myeloid/lymphoid or mixed-lineage leukemia 2

Synonyms

AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21;

Species

Homo sapiens

Ensembl Protein

ENSP00000301067

InnateDB Gene

IDBG-30867 (MLL2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001555	oocyte growth
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0043627	response to estrogen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048477	oogenesis
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0005634	nucleus
GO:0035097	histone methyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR003888 FY-rich, N-terminal
IPR003889 FY-rich, C-terminal
IPR009071 High mobility group box domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM