InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBR5

Summary

InnateDB Protein

IDBP-31167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR5

Protein Name

ubiquitin protein ligase E3 component n-recognin 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000220959

InnateDB Gene

IDBG-31165 (UBR5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	126 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0043130	ubiquitin binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0035413	positive regulation of catenin import into nucleus
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050847	progesterone receptor signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000569 HECT
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003126 Zinc finger, N-recognin
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR013993 Zinc finger, N-recognin, metazoa
IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain

PFAM

PF00632
PF00658
PF02207
PF11547

PRINTS

PIRSF

SMART

SM00119
SM00517
SM00396

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95071