InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRX3

Summary

InnateDB Protein

IDBP-31183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRX3

Protein Name

iroquois homeobox 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000331608

InnateDB Gene

IDBG-31181 (IRX3)

Protein Structure

UniProt Annotation

Function

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001656	metanephros development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007498	mesoderm development
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0072047	proximal/distal pattern formation involved in nephron development
GO:0072086	specification of loop of Henle identity