Version 5.4
Homo sapiens Gene: IRX3
Summary
InnateDB Gene IDBG-31181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRX3
Gene Name iroquois homeobox 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177508
Encoded Proteins
IDBP-31183
iroquois homeobox 3
IDBP-753393
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:54283304-54286763
Strand Reverse strand
Band q12.2
Transcripts
ENST00000329734 ENSP00000331608
ENST00000558054 ENSP00000463991
ENST00000558180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007498 mesoderm development
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0072047 proximal/distal pattern formation involved in nephron development
GO:0072086 specification of loop of Henle identity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031734
View Gene Order
ENSBTAG00000012083
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499205
RefSeq NM_024336
HUGO
OMIM
CCDS CCDS10750
HPRD 17162
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca