InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPO7

Summary

InnateDB Protein

IDBP-31282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPO7

Protein Name

importin 7

Synonyms

Imp7; RANBP7;

Species

Homo sapiens

Ensembl Protein

ENSP00000369042

InnateDB Gene

IDBG-31280 (IPO7)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269PubMed:10228156, ECO:0000269PubMed:12853482, ECO:0000269PubMed:9687515}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005215	transporter activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0042393	histone binding

Biological Process

GO:0006606	protein import into nucleus
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0016032	viral process
GO:0045087	innate immune response
GO:0050790	regulation of catalytic activity