Homo sapiens Gene: IPO7
Summary
InnateDB Gene IDBG-31280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPO7
Gene Name importin 7
Synonyms Imp7; RANBP7;
Species Homo sapiens
Ensembl Gene ENSG00000205339
Encoded Proteins
importin 7
importin 7
importin 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran\'s GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:9384622-9448126
Strand Forward strand
Band p15.4
Transcripts
ENST00000379719 ENSP00000369042
ENST00000533233 ENSP00000433313
ENST00000527431 ENSP00000435235
ENST00000533680
ENST00000528833
ENST00000531235
ENST00000530037
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005215 transporter activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0042393 histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0016032 viral process
GO:0045087 innate immune response
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O95373
TrEMBL B3KNG9 B3KQG6 E9PLB2 E9PLJ0
UniProt Splice Variant
Entrez Gene 10527
UniGene Hs.740445
RefSeq NM_006391
HUGO HGNC:9852
OMIM 605586
CCDS CCDS31425
HPRD
IMGT
EMBL AC055845 AC132192 AF098799 AJ295844 AK027487 AK027892 AK074908 AK312885 AL137335 BC114929 CH471064
GenPept AAC68903 AAI14930 BAG35733 BAG51331 BAG51391 BAG52028 CAB70698 CAC17609 EAW68593
RNA Seq Atlas 10527