InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFYVE16

Summary

InnateDB Protein

IDBP-31378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFYVE16

Protein Name

zinc finger, FYVE domain containing 16

Synonyms

PPP1R69;

Species

Homo sapiens

Ensembl Protein

ENSP00000337159

InnateDB Gene

IDBG-31374 (ZFYVE16)

Protein Structure

UniProt Annotation

Function

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269PubMed:11546807, ECO:0000269PubMed:14613930}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11546807}. Early endosome membrane {ECO:0000269PubMed:11546807}; Peripheral membrane protein {ECO:0000269PubMed:11546807}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. {ECO:0000269PubMed:11546807}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008565	protein transporter activity
GO:0046872	metal ion binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0007165	signal transduction
GO:0016050	vesicle organization
GO:0016197	endosomal transport
GO:0030100	regulation of endocytosis
GO:0030509	BMP signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017165 Zinc finger, FYVE-type, SARA/endofin
IPR017455 Zinc finger, FYVE-related
IPR022557 Domain of unknown function DUF3480

PFAM

PF01363
PF11979

PRINTS

PIRSF

PIRSF037289

SMART

SM00064

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt