InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGRF2

Summary

InnateDB Protein

IDBP-31654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRF2

Protein Name

Ras protein-specific guanine nucleotide-releasing factor 2

Synonyms

GRF2; RAS-GRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000265080

InnateDB Gene

IDBG-31650 (RASGRF2)

Protein Structure

UniProt Annotation

Function

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269PubMed:15128856}.

Subcellular Localization

Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). {ECO:0000269PubMed:10373510, ECO:0000269PubMed:11856323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007268	synaptic transmission
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00612
PF00621
PF00618
PF00169
PF00617

PRINTS

PIRSF

SMART

SM00015
SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14827