Homo sapiens Gene: RASGRF2
Summary
InnateDB Gene IDBG-31650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRF2
Gene Name Ras protein-specific guanine nucleotide-releasing factor 2
Synonyms GRF2; RAS-GRF2;
Species Homo sapiens
Ensembl Gene ENSG00000113319
Encoded Proteins
Ras protein-specific guanine nucleotide-releasing factor 2
Ras protein-specific guanine nucleotide-releasing factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:80960672-81230156
Strand Forward strand
Band q14.1
Transcripts
ENST00000265080 ENSP00000265080
ENST00000503795 ENSP00000421771
ENST00000514946
ENST00000502677
ENST00000512186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007268 synaptic transmission
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Neuronal System pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
NRAGE signals death through JNK pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Rho GTPase cycle pathway
Transmission across Chemical Synapses pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Regulation of RAC1 activity
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.162129 Hs.711031
RefSeq NM_006909 XM_005248565 XM_006714665
HUGO
OMIM
CCDS CCDS4052
HPRD 07588
IMGT
EMBL
GenPept
RNA Seq Atlas