InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSPG5

Summary

InnateDB Protein

IDBP-31815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSPG5

Protein Name

chondroitin sulfate proteoglycan 5 (neuroglycan C)

Synonyms

NGC;

Species

Homo sapiens

Ensembl Protein

ENSP00000373244

InnateDB Gene

IDBG-31813 (CSPG5)

Protein Structure

UniProt Annotation

Function

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269PubMed:15358134}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to brain (at protein level). {ECO:0000269PubMed:9950058}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007399	nervous system development
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0031103	axon regeneration
GO:0040008	regulation of growth
GO:0044281	small molecule metabolic process
GO:0046907	intracellular transport
GO:0050804	regulation of synaptic transmission

Cellular Component

GO:0005576	extracellular region
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005796	Golgi lumen
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0043202	lysosomal lumen