Homo sapiens Gene: CSPG5
Summary
InnateDB Gene IDBG-31813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSPG5
Gene Name chondroitin sulfate proteoglycan 5 (neuroglycan C)
Synonyms NGC;
Species Homo sapiens
Ensembl Gene ENSG00000114646
Encoded Proteins
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chondroitin sulfate proteoglycan 5 (neuroglycan C)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:47562239-47580792
Strand Reverse strand
Band p21.31
Transcripts
ENST00000383738 ENSP00000373244
ENST00000264723 ENSP00000264723
ENST00000456150 ENSP00000392096
ENST00000465441
ENST00000610462 ENSP00000478923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007399 nervous system development
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0031103 axon regeneration
GO:0040008 regulation of growth
GO:0044281 small molecule metabolic process
GO:0046907 intracellular transport
GO:0050804 regulation of synaptic transmission
Cellular Component
GO:0005576 extracellular region
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0043202 lysosomal lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
CS/DS degradation pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Chondroitin sulfate biosynthesis pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Dermatan sulfate biosynthesis pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95196
TrEMBL
UniProt Splice Variant
Entrez Gene 10675
UniGene Hs.45127
RefSeq NM_006574 NM_001206942 NM_001206943 NM_001206944 NM_001206945
HUGO HGNC:2467
OMIM 606775
CCDS CCDS2757 CCDS56252 CCDS56253 CCDS74930
HPRD
IMGT
EMBL AC099778 AC112512 AF059274 AF461087 AF461088 AF461089
GenPept AAC69612 AAQ04774 AAQ04775 AAQ04776
RNA Seq Atlas 10675