InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT21

Summary

InnateDB Protein

IDBP-31914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT21

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 21

Synonyms

CFIM25; CPSF5;

Species

Homo sapiens

Ensembl Protein

ENSP00000300291

InnateDB Gene

IDBG-31912 (NUDT21)

Protein Structure

UniProt Annotation

Function

Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269PubMed:14690600, ECO:0000269PubMed:20479262, ECO:0000269PubMed:20695905, ECO:0000269PubMed:21295486, ECO:0000269PubMed:8626397, ECO:0000269PubMed:9659921}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15169763, ECO:0000269PubMed:20695905, ECO:0000269PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.

Experimentally validated
Total	139 [view]
Protein-Protein	138 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0017091	AU-rich element binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0051262	protein tetramerization