InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPO

Summary

InnateDB Protein

IDBP-31943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPO

Protein Name

erythropoietin

Synonyms

EP; MVCD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000252723

InnateDB Gene

IDBG-31941 (EPO)

Protein Structure

UniProt Annotation

Function

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Subcellular Localization

Secreted.

Disease Associations

Microvascular complications of diabetes 2 (MVCD2) [MIM:612623]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	3 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005128	erythropoietin receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001666	response to hypoxia
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008015	blood circulation
GO:0008284	positive regulation of cell proliferation
GO:0009651	response to salt stress
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0018105	peptidyl-serine phosphorylation
GO:0030218	erythrocyte differentiation
GO:0032496	response to lipopolysaccharide
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0033189	response to vitamin A
GO:0033574	response to testosterone
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042541	hemoglobin biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043249	erythrocyte maturation
GO:0043627	response to estrogen
GO:0045666	positive regulation of neuron differentiation
GO:0045740	positive regulation of DNA replication
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048678	response to axon injury
GO:0051602	response to electrical stimulus
GO:0055093	response to hyperoxia
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070555	response to interleukin-1
GO:0071456	cellular response to hypoxia
GO:0071474	cellular hyperosmotic response
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902251	negative regulation of erythrocyte apoptotic process
GO:2001258	negative regulation of cation channel activity