InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4G2

Summary

InnateDB Protein

IDBP-31986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4G2

Protein Name

eukaryotic translation initiation factor 4 gamma, 2

Synonyms

AAG1; DAP5; NAT1; P97;

Species

Homo sapiens

Ensembl Protein

ENSP00000340281

InnateDB Gene

IDBG-31984 (EIF4G2)

Protein Structure

UniProt Annotation

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269PubMed:11511540, ECO:0000269PubMed:11943866, ECO:0000269PubMed:9032289, ECO:0000269PubMed:9049310}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney. {ECO:0000269PubMed:9030685, ECO:0000269PubMed:9032289, ECO:0000269PubMed:9049310}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0007050	cell cycle arrest
GO:0008219	cell death
GO:0019221	cytokine-mediated signaling pathway