Version 5.4
Homo sapiens Gene: EIF4G2
Summary
InnateDB Gene IDBG-31984.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4G2
Gene Name eukaryotic translation initiation factor 4 gamma, 2
Synonyms AAG1; DAP5; NAT1; P97
Species Homo sapiens
Ensembl Gene ENSG00000110321
Encoded Proteins
IDBP-31986
eukaryotic translation initiation factor 4 gamma, 2
IDBP-237289
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604112
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604113
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604114
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604115
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604116
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604117
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604118
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604119
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604120
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604121
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604122
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604123
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604126
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604127
eukaryotic translation initiation factor 4 gamma, 2
IDBP-604128
eukaryotic translation initiation factor 4 gamma, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10797050-10809110
Strand Reverse strand
Band p15.4
Transcripts
ENST00000339995 ENSP00000340281
ENST00000396525 ENSP00000379778
ENST00000526148 ENSP00000433664
ENST00000525681 ENSP00000433371
ENST00000532383
ENST00000532120
ENST00000525606
ENST00000534470
ENST00000534272
ENST00000528839 ENSP00000434815
ENST00000531180 ENSP00000433561
ENST00000530564
ENST00000531416 ENSP00000431583
ENST00000531647 ENSP00000433217
ENST00000532082 ENSP00000433121
ENST00000532349
ENST00000524932 ENSP00000435523
ENST00000527015
ENST00000534605 ENSP00000436680
ENST00000532152
ENST00000527419 ENSP00000434940
ENST00000531507
ENST00000525972
ENST00000528562 ENSP00000435220
ENST00000532570 ENSP00000431511
ENST00000530211 ENSP00000433335
ENST00000527526 ENSP00000436235
ENST00000530702 ENSP00000435912
ENST00000525995
ENST00000533485
ENST00000534246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0007050 cell cycle arrest
GO:0008219 cell death
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005610
View Gene Order
ENSBTAG00000020308
Not yet available
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa05416
Viral myocarditis pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.183684
RefSeq NM_001042559 NM_001172705 NM_001418
HUGO
OMIM
CCDS CCDS31428 CCDS41618
HPRD 09084
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca