InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYMS

Summary

InnateDB Protein

IDBP-321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMS

Protein Name

thymidylate synthetase

Synonyms

HST422; TMS; TS;

Species

Homo sapiens

Ensembl Protein

ENSP00000315644

InnateDB Gene

IDBG-319 (TYMS)

Protein Structure

UniProt Annotation

Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269PubMed:21876188}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21876188}. Cytoplasm {ECO:0000269PubMed:21876188}. Mitochondrion {ECO:0000269PubMed:21876188}. Mitochondrion matrix {ECO:0000269PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269PubMed:21876188}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	40 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003729	mRNA binding
GO:0004799	thymidylate synthase activity
GO:0005542	folic acid binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006139	nucleobase-containing compound metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006231	dTMP biosynthetic process
GO:0006235	dTTP biosynthetic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0019088	immortalization of host cell by virus
GO:0019860	uracil metabolic process
GO:0031100	organ regeneration
GO:0032259	methylation
GO:0032570	response to progesterone
GO:0033189	response to vitamin A
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046078	dUMP metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046683	response to organophosphorus
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048589	developmental growth
GO:0051216	cartilage development
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060574	intestinal epithelial cell maturation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol