Homo sapiens Gene: TYMS
Summary
InnateDB Gene IDBG-319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYMS
Gene Name thymidylate synthetase
Synonyms HST422; TMS; TS;
Species Homo sapiens
Ensembl Gene ENSG00000176890
Encoded Proteins
thymidylate synthetase
thymidylate synthetase
thymidylate synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:657604-673578
Strand Forward strand
Band p11.32
Transcripts
ENST00000323274 ENSP00000315644
ENST00000323224 ENSP00000314727
ENST00000323250 ENSP00000314902
ENST00000584122
ENST00000581920
ENST00000579128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 40 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003729 mRNA binding
GO:0004799 thymidylate synthase activity
GO:0005542 folic acid binding
GO:0008144 drug binding
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006139 nucleobase-containing compound metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019088 immortalization of host cell by virus
GO:0019860 uracil metabolic process
GO:0031100 organ regeneration
GO:0032259 methylation
GO:0032570 response to progesterone
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046078 dUMP metabolic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046683 response to organophosphorus
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048589 developmental growth
GO:0051216 cartilage development
GO:0051384 response to glucocorticoid
GO:0051593 response to folic acid
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060574 intestinal epithelial cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
G1/S-Specific Transcription pathway
Cell Cycle pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
E2F mediated regulation of DNA replication pathway
Cell Cycle, Mitotic pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
KEGG
Pyrimidine metabolism pathway
One carbon pool by folate pathway
INOH
Folate metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001071
HUGO
OMIM
CCDS CCDS11821
HPRD 01774
IMGT
EMBL
GenPept
RNA Seq Atlas