InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TYMS

Summary

InnateDB Gene

IDBG-319.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMS

Gene Name

thymidylate synthetase

Synonyms

HST422; TMS; TS

Species

Homo sapiens

Ensembl Gene

ENSG00000176890

Encoded Proteins

IDBP-321

thymidylate synthetase

IDBP-323

thymidylate synthetase

IDBP-325

thymidylate synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:657604-673578

Strand

Forward strand

Band

p11.32

Transcripts

ENST00000323274	ENSP00000315644
ENST00000323224	ENSP00000314727
ENST00000323250	ENSP00000314902
ENST00000584122
ENST00000581920
ENST00000579128

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	40 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003729	mRNA binding
GO:0004799	thymidylate synthase activity
GO:0005542	folic acid binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006139	nucleobase-containing compound metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006231	dTMP biosynthetic process
GO:0006235	dTTP biosynthetic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0019088	immortalization of host cell by virus
GO:0019860	uracil metabolic process
GO:0031100	organ regeneration
GO:0032259	methylation
GO:0032570	response to progesterone
GO:0033189	response to vitamin A
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046078	dUMP metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046683	response to organophosphorus
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048589	developmental growth
GO:0051216	cartilage development
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060574	intestinal epithelial cell maturation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol