InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AQP5

Summary

InnateDB Protein

IDBP-32147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP5

Protein Name

aquaporin 5

Synonyms

AQP-5; PPKB;

Species

Homo sapiens

Ensembl Protein

ENSP00000293599

InnateDB Gene

IDBG-32145 (AQP5)

Protein Structure

UniProt Annotation

Function

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231]: A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections. {ECO:0000269PubMed:23830519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015250	water channel activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0007588	excretion
GO:0015670	carbon dioxide transport
GO:0030157	pancreatic juice secretion
GO:0042476	odontogenesis
GO:0046541	saliva secretion
GO:0048593	camera-type eye morphogenesis
GO:0055085	transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome