Homo sapiens Gene: AQP5
Summary
InnateDB Gene IDBG-32145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP5
Gene Name aquaporin 5
Synonyms AQP-5; PPKB;
Species Homo sapiens
Ensembl Gene ENSG00000161798
Encoded Proteins
aquaporin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:49961870-49965681
Strand Forward strand
Band q13.12
Transcripts
ENST00000293599 ENSP00000293599
ENST00000553132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015250 water channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0007588 excretion
GO:0015670 carbon dioxide transport
GO:0030157 pancreatic juice secretion
GO:0042476 odontogenesis
GO:0046541 saliva secretion
GO:0048593 camera-type eye morphogenesis
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Passive transport by Aquaporins pathway
Aquaporin-mediated transport pathway
KEGG
Salivary secretion pathway
INOH
PID BIOCARTA
PID NCI
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt P55064
TrEMBL
UniProt Splice Variant
Entrez Gene 362
UniGene Hs.298023
RefSeq NM_001651
HUGO HGNC:638
OMIM 600442
CCDS CCDS8793
HPRD
IMGT
EMBL BC032946 CR541989 CR542022 U46566 U46567 U46568 U46569
GenPept AAC50474 AAH32946 CAG46786 CAG46819
RNA Seq Atlas 362