InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYMS

Summary

InnateDB Protein

IDBP-323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMS

Protein Name

thymidylate synthetase

Synonyms

HST422; TMS; TS;

Species

Homo sapiens

Ensembl Protein

ENSP00000314727

InnateDB Gene

IDBG-319 (TYMS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004799	thymidylate synthase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006139	nucleobase-containing compound metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006231	dTMP biosynthetic process
GO:0006235	dTTP biosynthetic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0032259	methylation
GO:0044281	small molecule metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0046683	response to organophosphorus
GO:0048015	phosphatidylinositol-mediated signaling
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol