InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICAL2

Summary

InnateDB Protein

IDBP-32319.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICAL2

Protein Name

microtubule associated monoxygenase, calponin and LIM domain containing 2

Synonyms

MICAL-2; MICAL2PV1; MICAL2PV2;

Species

Homo sapiens

Ensembl Protein

ENSP00000256194

InnateDB Gene

IDBG-32315 (MICAL2)

Protein Structure

UniProt Annotation

Function

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine- sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. {ECO:0000269PubMed:23927065, ECO:0000269PubMed:24440334}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:24440334}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0043914	NADPH:sulfur oxidoreductase activity
GO:0071949	FAD binding

Biological Process

GO:0001947	heart looping
GO:0007010	cytoskeleton organization
GO:0007507	heart development
GO:0010735	positive regulation of transcription via serum response element binding
GO:0019417	sulfur oxidation
GO:0030042	actin filament depolymerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR002938 Monooxygenase, FAD-binding
IPR003042 Aromatic-ring hydroxylase-like
IPR003953 FAD binding domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00412
PF01494
PF00890
PF11971

PRINTS

PR00420

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt