InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOB

Summary

InnateDB Protein

IDBP-32469.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOB

Protein Name

ras homolog gene family, member B

Synonyms

ARH6; ARHB; MST081; MSTP081; RHOH6;

Species

Homo sapiens

Ensembl Protein

ENSP00000272233

InnateDB Gene

IDBG-32465 (RHOB)

Protein Structure

UniProt Annotation

Function

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269PubMed:10508588, ECO:0000269PubMed:15226397, ECO:0000269PubMed:16236794, ECO:0000269PubMed:21373644, ECO:0000269PubMed:9478917}.

Subcellular Localization

Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0000910	cytokinesis
GO:0001525	angiogenesis
GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0043065	positive regulation of apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0045786	negative regulation of cell cycle
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0070301	cellular response to hydrogen peroxide
GO:0071479	cellular response to ionizing radiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt