Homo sapiens Gene: RHOB
Summary
InnateDB Gene IDBG-32465.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOB
Gene Name ras homolog family member B
Synonyms ARH6; ARHB; MST081; MSTP081; RHOH6;
Species Homo sapiens
Ensembl Gene ENSG00000143878
Encoded Proteins
ras homolog gene family, member B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:20447074-20449445
Strand Forward strand
Band p24.1
Transcripts
ENST00000272233 ENSP00000272233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0000910 cytokinesis
GO:0001525 angiogenesis
GO:0006184 GTP catabolic process
GO:0006915 apoptotic process
GO:0006927 transformed cell apoptotic process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0030168 platelet activation
GO:0043065 positive regulation of apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0045786 negative regulation of cell cycle
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070301 cellular response to hydrogen peroxide
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0032154 cleavage furrow
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Semaphorin interactions pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPVI-mediated activation cascade pathway
Rho GTPase cycle pathway
Sema4D induced cell migration and growth-cone collapse pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62745
TrEMBL B4DMJ8
UniProt Splice Variant
Entrez Gene 388
UniGene Hs.502876
RefSeq NM_004040
HUGO HGNC:668
OMIM 165370
CCDS CCDS1699
HPRD 01321
IMGT
EMBL AC023137 AF498971 AK124398 AK297495 AK312487 BC066954 BK001232 BK001671 BT019546 BT019547 CH471053 CR542272 M12174 X06820
GenPept AAA36565 AAH66954 AAM21118 AAV38353 AAV38354 AAY24345 BAG35389 BAG54035 BAG59910 CAA29968 CAG47068 DAA01138 DAA01912 EAX00819 EAX00820
RNA Seq Atlas 388