InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRT17

Summary

InnateDB Protein

IDBP-32532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT17

Protein Name

keratin 17

Synonyms

K17; PC; PC2; PCHC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000308452

InnateDB Gene

IDBG-32530 (KRT17)

Protein Structure

UniProt Annotation

Function

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. {ECO:0000269PubMed:10571744, ECO:0000269PubMed:11348474, ECO:0000269PubMed:11874497, ECO:0000269PubMed:11886499, ECO:0000269PubMed:15102078, ECO:0000269PubMed:15795125, ECO:0000269PubMed:16620218, ECO:0000269PubMed:16625196, ECO:0000269PubMed:7539673, ECO:0000269PubMed:9008238, ECO:0000269PubMed:9767294}. Note=The disease is caused by mutations affecting the gene represented in this entry.Steatocystoma multiplex (SM) [MIM:184500]: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. {ECO:0000269PubMed:16620218, ECO:0000269PubMed:9008238, ECO:0000269PubMed:9767294}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Tissue Specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). {ECO:0000269PubMed:10651700, ECO:0000269PubMed:10844551, ECO:0000269PubMed:1281771, ECO:0000269PubMed:2481679}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0032395	MHC class II receptor activity
GO:0042289	MHC class II protein binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0007165	signal transduction
GO:0008544	epidermis development
GO:0030307	positive regulation of cell growth
GO:0031424	keratinization
GO:0045109	intermediate filament organization
GO:0045727	positive regulation of translation
GO:0051798	positive regulation of hair follicle development