Version 5.4
Homo sapiens Gene: KRT17
Summary
InnateDB Gene IDBG-32530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT17
Gene Name keratin 17
Synonyms K17; PC; PC2; PCHC1;
Species Homo sapiens
Ensembl Gene ENSG00000128422
Encoded Proteins
IDBP-32532
keratin 17
IDBP-760151
IDBP-758933
IDBP-763526
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:41619437-41624842
Strand Reverse strand
Band q21.2
Transcripts
ENST00000311208 ENSP00000308452
ENST00000493253
ENST00000463128 ENSP00000468672
ENST00000491673
ENST00000590038 ENSP00000466166
ENST00000577817 ENSP00000467418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0032395 MHC class II receptor activity
GO:0042289 MHC class II protein binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0030307 positive regulation of cell growth
GO:0031424 keratinization
GO:0045109 intermediate filament organization
GO:0045727 positive regulation of translation
GO:0051798 positive regulation of hair follicle development
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000035557
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000006806
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000422
HUGO
OMIM
CCDS CCDS11402
HPRD 01019
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca