Homo sapiens Gene: KRT17
Summary
InnateDB Gene IDBG-32530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT17
Gene Name keratin 17
Synonyms K17; PC; PC2; PCHC1;
Species Homo sapiens
Ensembl Gene ENSG00000128422
Encoded Proteins
keratin 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:41619437-41624842
Strand Reverse strand
Band q21.2
Transcripts
ENST00000311208 ENSP00000308452
ENST00000493253
ENST00000463128 ENSP00000468672
ENST00000491673
ENST00000590038 ENSP00000466166
ENST00000577817 ENSP00000467418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0032395 MHC class II receptor activity
GO:0042289 MHC class II protein binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0030307 positive regulation of cell growth
GO:0031424 keratinization
GO:0045109 intermediate filament organization
GO:0045727 positive regulation of translation
GO:0051798 positive regulation of hair follicle development
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000422
HUGO
OMIM
CCDS CCDS11402
HPRD 01019
IMGT
EMBL
GenPept
RNA Seq Atlas