InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLD6

Summary

InnateDB Protein

IDBP-32728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD6

Protein Name

phospholipase D family, member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317177

InnateDB Gene

IDBG-32726 (PLD6)

Protein Structure

UniProt Annotation

Function

Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol. {ECO:0000250, ECO:0000269PubMed:17028579, ECO:0000269PubMed:21397848}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:17028579}; Single-pass membrane protein {ECO:0000269PubMed:17028579}.

Disease Associations

Tissue Specificity

Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269PubMed:17028579, ECO:0000269PubMed:21397847}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004519	endonuclease activity
GO:0035755	cardiolipin hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0007126	meiotic nuclear division
GO:0007286	spermatid development
GO:0008053	mitochondrial fusion
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0030719	P granule organization
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis